Time-Dependent Effects of Buspirone versus Desipramine on the 5-Choice Serial Reaction Time Task in Rats Reared in Social Isolation: Implication of Early Life Experience and Motoric Impulsivity

Background: Early life social experience and the function of central serotonin (5-Hydroxytryptophan, 5-HT) system are involved in development behavioral impulsivity which individuals act without forethought or before all necessary information is available. However, most evidence has been obtained from acute 5-HT manipulation, whereas, present study aimed to investigate effects subchronic regimen targeting 5-HT1A receptors on motoric waiting socially isolated rats. Methods: A two-week protocol buspirone (0.5 mg/kg/day) desipramine (2.5 was employed for rats following isolation rearing (IR) examine their performance a 5-choice serial reaction time task (5-CSRTT) during treatment regimen. Responses any one apertures prior an informative signal were recorded as premature response. Results: IR presented with more locomotor activity than reared (SR) Buspirone progressively increased baseline level responding time-dependent manner that not observed Both SR exhibited less challenge. For regimen, followed same trend controls increase prematurity Conclusions: but desipramine-induced can be reversed by IR, indicating role early receptor-associated ability control impulsiveness.